| melting | computing the melting temperature of nucleic acid duplex | Mehr ... |
This program computes, for a nucleic acid duplex, the enthalpy, the
entropy and the melting temperature of the helix-coil
transitions. Three types of hybridisation are possible: DNA/DNA,
DNA/RNA, and RNA/RNA. The program first computes the hybridisation
enthalpy and entropy from the elementary parameters of each Crick's
pair by the nearest-neighbor method. Then the melting temperature is
computed. The set of thermodynamic parameters can be easily changed,
for instance following an experimental breakthrough. Melting was
published in Le Novère N. (2001), Bioinformatics, 17: 1226-1227. |
| melting-gui | Graphical user interface for melting | Mehr ... |
